Virus Papiloma Humano: Un enemigo silencioso en el Ecuador y el mundo.

Autores/as

Julia Irma Carrión Ordóñez
Universidad Católica de Cuenca
https://orcid.org/0000-0003-0395-9762
Sara Elizabeth Bravo Salinas
Universidad Católica de Cuenca
https://orcid.org/0000-0003-4878-1662
Fabian Alejandro Escandón Carrión
Universidad Católica de Cuenca
https://orcid.org/0000-0002-5284-3910
María Augusta Escandón Carrión
Universidad Católica de Cuenca
https://orcid.org/0000-0001-7927-8707

Palabras clave:

virus, papilomavirus, cáncer

Sinopsis

PRÓLOGO

El Virus del papiloma humano (en adelante HPV) es una infección de transmisión sexual que, por lo general, afecta mayoritariamente las mucosas orales y genitales, causa crecimiento (conocidas como vegetaciones o verrugas) en piel o membranas mucosas, existiendo más de 200 variedades del virus, siendo causantes de patologías benignas en la mayor parte de pacientes, sin embargo, alguno tipos son los causantes de varios cánceres como cáncer de ano, pene, vagina, vulva u orofaringe, siendo el cáncer cervical el más frecuente, constituyéndose este último en uno de los cánceres más silenciosos, siendo el cuarto tipo de cáncer más frecuente en las mujeres a nivel mundial, por lo que se ha vuelto un problema de salud pública a nivel global.

A pesar de las múltiples patologías causadas por el HPV, en la actualidad existen vacunas para la protección contra las cepas que puedan causar tanto verrugas genitales o cáncer de cuello del útero, aunque en la mayoría de casos el sistema inmunitario vence la infección del virus antes de crear las verrugas. Muchas veces, han transcurrido semanas o meses, incluso años, antes de su aparición y el tipo de verrugas estará determinado por la cepa del virus.

En el caso del cáncer cervical el desarrollo del mismo puede tardar hasta veinte años o más después de una infección por el HPV, siendo muy silencioso los primeros estadios, lo que se puede evidenciar con una prueba de Papanicolaou, por lo que hoy en día es imprescindible la promoción de un adecuado chequeo ginecológico, sobre todo, en mujeres sexualmente activas, en período fértil e incluso posmenopáusicas. Aunque las mujeres mayores de 65 años también pueden hacerse un Papanicolau, éstas pueden dejar de hacerse la prueba si se han obtenido resultados normales en tres pruebas de Papanicolaou seguidas o si se hicieron dos análisis de ADN del virus del papiloma humano y pruebas de Papanicolaou sin resultados anormales.

En cualquier caso, un chequeo y una prueba a tiempo pueden permitir una adecuada pesquisa, instaurando un tratamiento adecuado dependiendo del grado de afectación, que influya de forma positiva en el futuro del individuo, su familia y su entorno. Por ende, este libro describe las principales características del virus y los principales hallazgos en la población ecuatoriana.

Sara Elizabeth Bravo Salinas

Médico especialista en Medicina Familiar y Comunitaria

Máster en Atención de pacientes con VIH

Especialista en Docencia Universitaria

Universidad Católica de Cuenca

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Biografía del autor/a

Julia Irma Carrión Ordóñez , Universidad Católica de Cuenca

Doctora en Medicina y Cirugía
Magister en Docencia Universitaria e
Investigación educativa
Magister en Salud Integral del Adolescente
Doctora en Ciencias biológicas

Sara Elizabeth Bravo Salinas, Universidad Católica de Cuenca

Especialista en Medicina Familiar y Comunitaria
Máster en Atención de pacientes con VIH
Especialista en Docencia Universitaria

Fabian Alejandro Escandón Carrión, Universidad Católica de Cuenca

Médico General

María Augusta Escandón Carrión, Universidad Católica de Cuenca

Médico General

Citas

Zur Hausen H. Papillomaviruses in the causation of human cancers - a brief historical account. Virology. 2009;384(2):260-5.

Leto MG, Santos Junior GF, Porro AM, Tomimori J. Human papillomavirus infection: etiopathogenesis, molecular biology and clinical manifestations. An Bras Dermatol. 2011;86(2):306-17.

Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I. Human papillomavirus molecular biology and disease association. Rev Med Virol 2015;25(6):2-23.

Arbyn M, Simoens C, Van Damme P, Scharpantgen A, Meijer CJ, Beutels P. Introduction of human papillomavirus vaccination in Belgium, Luxembourg and the Netherlands. Gynecol Obstet Invest. 2010;70(4):224-32.

de Martel C, Ferlay J, Franceschi S, Forman D, Lacey CJ, Soerjomataram I, et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012;30 (5):F12-23.

Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012;30 (5):F12-23.

de Villiers EM. Cross-roads in the classification of papillomaviruses. Virology. 2013;445(1-2):2-10.

Mukakalisa I, Bindler R, Allen C, Dotson J. Cervical cancer in developing countries: effective screening and preventive strategies with an application in Rwanda. Health Care Women Int. 2014;35(7-9):1065-80.

Islami F, Fedewa SA, Jemal A. Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States. Prev Med. 2019;123:316-23.

Osazuwa-Peters N, Adjei Boakye E, Rohde RL, Ganesh RN, Moiyadi AS, Hussaini AS, et al. Understanding of risk factors for the human papillomavirus (HPV) infection based on gender and race. Sci Rep. 2019;9(1):297.

Bruni L, Alberto G, Serrano B, Mena M, Gómez D, Muñoz J, et al. Human Papillomavirus and Related Diseases in the World. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre) Summary Report 17. 2019.

SOLCA RN. Epidemiología del Cáncer en Quito 2003-2005 In: INEC-MSP, editor. Quito. Ecuador: SOLCA; 2009.

Cecchini G, Paganini G, D'Amico M, Cannone M, Bertuletti C, Barberis MC. Cervical cancer screening programs in low-income communities. Experiences from Ecuador. Low cost detection of HPV infection in a developing country. Pathologica. 2009;101(2):76-9.

Vaccarella S, Lortet-Tieulent J, Plummer M, Franceschi S, Bray F. Worldwide trends in cervical cancer incidence: impact of screening against changes in disease risk factors. Eur J Cancer. 2013;49(15):3262-73.

Serrano B, Brotons M, Bosch FX, Bruni L. Epidemiology and burden of HPV-related disease. Best Pract Res Clin Obstet Gynaecol. 2018;47:14-26.

de Sanjosé S, Serrano B, Tous S, Alejo M, Lloveras B, Quiros B, et al. Burden of Human Papillomavirus (HPV)-Related Cancers Attributable to HPVs 6/11/16/18/31/33/45/52 and 58. JNCI cancer spectrum. 2018;2(4):pky045.

Nogueira-Rodrigues A, Bukowski EP, St. Louis J, Barrichello A, Sternberg C, Gifoni MAC, et al. An Alert to Latin America: Current Human Papillomavirus Vaccination Trends Highlight Key Barriers to Successful Implementation Cancer. 2017.

Basto DL, Vidal JP, Pontes VB, Felix SP, Pinto LC, Soares BM, et al. Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil. Arch Virol. 2017;162(9):2855-60.

Marin HM, Torres C, Deluca GD, Mbayed VA. Human papillomavirus detection in Corrientes, Argentina: High prevalence of type 58 and its phylodynamics. Rev Argent Microbiol. 2015;47(4):302-11.

Sanchez GI, Bravo LE, Hernandez-Suarez G, Tous S, Alemany L, de San José S, et al. Secular trends of HPV genotypes in invasive cervical cancer in Cali, Colombia 1950-1999. Cáncer Epidemiol. 2016;40:173-8.

Bedoya-Pilozo CH, Medina Magues LG, Espinosa-Garcia M, Sanchez M, Parrales Valdiviezo JV, Molina D, et al. Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador. Rev Argent Microbiol. 2018;50(2):136-46.

Mejia L, Munoz D, Trueba G, Tinoco L, Zapata S. Prevalence of human papillomavirus types in cervical cancerous and precancerous lesions of Ecuadorian women. J Med Virol. 2016;88(1):144-52.

Garcia Muentes GD, Garcia Rodriguez LK, Burgos Galarraga RI, Almeida Carpio F, Ruiz Cabezas JC. Genotypes distribution of human papillomavirus in cervical samples of Ecuadorian women. Revista brasileira de epidemiologia = Brazilian journal of epidemiology. 2016;19(1):160-6.

Tobar P, Vega M, Ordonez C, Rivera L, Landivar J, Zambrano H. Detection of Zika Virus and Human Papilloma Virus in Cervical Cytology Samples using Two Real Time PCR Based Techniques in Ecuadorian Women diagnosed with ASCUS. P R Health Sci J. 2018;37(Special Issue):96-8.

Petry KU, Schmidt D, Scherbring S, Luyten A, Reinecke-Luthge A, Bergeron C, et al. Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology. Gynecol Oncol. 2011;121(3):505-9.

Mancilla JC. Public expenditure in health in Ecuador. Rev Med FCM-UCSG 2012;18(1):53-60.

SOLCA BE. Incidencia de cáncer en el Hospital de SOLCA de Guayaquil, 2013-2017. In: INEC-MSP, editor. Guayaquil, Ecuador: SOLCA; 2017. p. 1-12.

Suescún-Tarazona D. Interpretación del informe de la citología cervical de acuerdo al Sistema Bethesda 2001 Medicina & Laboratorio. 2005;11:479-90.

De Sanjose S. Historia de cribado en mujeres con cáncer infiltrante de cuello uterino. Gaceta Sanitaria. 2006;20:166-70.

Muñoz G, Mota L, Bowie WR, Quizhpe A, E. O, Spiegel JM, et al. Ecosystem approach to promoting appropriate antibiotic use for children in indigenous communities in Ecuador. Rev Panam Salud Publica. 2011;30(6):566-73.

Burgos-Guevara H. La identidad del pueblo cañari: De-construcción de una nación étnica EEUU: Abya-Yala; 2003.

Ecuador SdLceCd. Estrategia Nacional para la atención integral del cáncer en el Ecuador. In: INEC-MSP, editor. Ecuador: Quito, Ecuador; 2017.

Fernandes JV, Galvão de Araújo JM, Araújo de Medeiros Fernandes TA. Biology and natural history of human papillomavirus infection. J Clin Trials. 2013;5 1-12.

Sellors J, Sankaranarayanan R. An introduction to the anatomy of the uterine cervix. Colposcopy and treatment of Cervical Intraepithelial Neoplasia: A beginners manual 2003.

Grover A, Pandey D. Colposcopy of Female Genital Tract. S. Mehta PS, editor. Singapore Springer Science & Business Media Singapore 2017.

Nicolau UR, de Jesus VHF, Lima ENP, Alves MS, de Oliveira TB, Andrade LB, et al. Early metabolic 18F-FDG PET/CT response of locally advanced squamous-cell carcinoma of head and neck to induction chemotherapy: A prospective pilot study. PLoS One. 2018;13(8):e0200823.

Lancaster WD, Olson C. Animal papillomaviruses. Microbiol Rev. 1982;46(2):191-207.

Sundberg JP. Papillomaviruses and Human Diseases. In: Syrjanen K, Gissmann LL, Koss LG, editors. Papillomavirus infections in animals. Berlin: Springer-Verlag; 1987. p. 40-103.

Danos O, Engel LW, Chen EY, Yaniv M, Howley PM. Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes. J Virol. 1983;46(2):557-66.

Dollard SC, Wilson JL, Demeter LM, Bonnez W, Reichman RC, Broker TR, et al. Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. OFF. Genes Dev. 1992;6(7):1131-42.

Zur Hausen H, Gissmann L, Steiner W, Dippold W, Dreger I. Los viruses y el cáncer. Bibl Haematol. 1975(43):569-71.

Durst M, Gissmann L, Ikenberg H, Zur Hausen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A. 1983;80(12):3812-5.

Munoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518-27.

Kumaraswamy KL, Vidhya M. Human papilloma virus and oral infections: an update. J Cancer Res Ther. 2011;7(2):120-7.

Kuhs KA, Porras C, Schiller JT, Rodriguez AC, Schiffman M, Gonzalez P, et al. Effect of different human papillomavirus serological and DNA criteria on vaccine efficacy estimates. Am J Epidemiol. 2014;180(6):599-607.

Bernard HU. Taxonomy and phylogeny of papillomaviruses: an overview and recent developments. Infect Genet Evol. 2013;18:357-61.

Van Doorslaer K, Chen Z, Bernard HU, Chan PKS, DeSalle R, Dillner J, et al. ICTV Virus Taxonomy Profile: Papillomaviridae. J Gen Virol. 2018;99(8):989-90.

de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H. Classification of papillomaviruses. Virology. 2004;324(1):17-27.

Bernard HU, Burk RD, Chen Z, van Doorslaer K, Hausen H, de Villiers EM. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology. 2010;401(1):70-9.

Chen Z, Terai M, Fu L, Herrero R, DeSalle R, Burk RD. Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses. J Virol. 2005;79(11):7014- 23.

Burk RD, Harari A, Chen Z. Human papillomavirus genome variants. Virology. 2013;445(1-2):232-43.

Vilata-Corell JJ. Infección por el virus del papiloma humano (VPH). Prog Obs Ginecol. 2016;21(44):289-323.

Howley PM, Lowy DR. Papillomaviruses. In: Knipe DM, Howley PM, editors. Fields Virology. II. 5th ed. Philadelphia, USA: Lippincott Williams & Wilkins; 2007. p. 2300-54.

Schiffman M, Herrero R, Desalle R, Hildesheim A, Wacholder S, Rodriguez AC, et al. The carcinogenicity of human papillomavirus types reflects viral evolution. Virology. 2005;337(1):76-84.

Dalgo Aguilar P, Lojan Gonzalez C, Cordova Rodriguez A, Acurio Paez K, Arevalo AP, Bobokova J. Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador. Infect Dis Obstet Gynecol. 2017;2017:8572065.

Zheng ZM, Baker CC. Papillomavirus genome structure, expression, and post- transcriptional regulation. Front Biosci. 2006;11:2286-302.

Cripe TP, Haugen TH, Turk JP, Tabatabai F, Schmid PG, 3rd, Durst M, et al. Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte- dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis. EMBO J. 1987;6(12):3745-53.

Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, et al. The biology and life- cycle of human papillomaviruses. Vaccine. 2012;30 Suppl 5:F55-70.

Jagu S, Kwak K, Garcea RL, Roden RB. Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection. Vaccine. 2010;28(28):4478-86.

Vande Pol SB, Klingelhutz AJ. Papillomavirus E6 oncoproteins. Virology. 2013;445(1- 2):115-37.

Moody CA, Laimins LA. Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer. 2010;10(8):550-60.

Rautava J, Syrjanen S. Biology of human papillomavirus infections in head and neck carcinogenesis. Head Neck Pathol. 2012;6 Suppl 1:S3-15.

Letian T, Tianyu Z. Cellular receptor binding and entry of human papillomavirus. Virol J. 2010;7:2.

Baseman JG, Koutsky LA. The epidemiology of human papillomavirus infections. J Clin Virol. 2005;32 Suppl 1:S16-24.

Burchell AN, Winer RL, de Sanjose S, Franco EL. Chapter 6: Epidemiology and transmission dynamics of genital HPV infection. Vaccine. 2006;24 Suppl 3:S3/52-61.

Van Doorslaer K, Chen D, Chapman S, Khan J, McBride AA. Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer. mBio. 2017;8(6).

Moscicki AB, Schiffman M, Kjaer S, Villa LL. Chapter 5: Updating the natural history of HPV and anogenital cancer. Vaccine. 2006;24 Suppl 3:S3/42-51.

Stanley MA, Sterling JC. Host responses to infection with human papillomavirus. Curr Probl Dermatol. 2014;45:58-74.

Doorbar J. Latent papillomavirus infections and their regulation. Curr Opin Virol. 2013;3(4):416-21.

Frazer IH. Prevention of cervical cancer through papillomavirus vaccination. Nat Rev Immunol. 2004;4(1):46-54.

Hamid NA, Brown C, Gaston K. The regulation of cell proliferation by the papillomavirus early proteins. Cell Mol Life Sci. 2009;66(10):1700-17.

Trottier H, Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine. 2006;24 Suppl 1:S1-15.

Bodily J, Laimins LA. Persistence of human papillomavirus infection: keys to malignant progression. Trends Microbiol. 2011;19(1):33-9.

Diaz D, Santander MA, Chavez JA. HPV-16 E6 and E7 oncogene expression is downregulated as a result of Mdm2 knockdown. Int J Oncol. 2012;41(1):141-6.

Perez-Plasencia C, Duenas-Gonzalez A, Alatorre-Tavera B. Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway. Int Arch Med. 2008;1(1):10.

Van Doorslaer K, Burk RD. Evolution of human papillomavirus carcinogenicity. Adv Virus Res. 2010;77:41-62.

Howley PM, Lowy DR. Papillomaviruses. In: Knipe DM, Howley PM, editors. Fields Virology, 5th Edition: Lippincott Williams & Wilkins; 2007. p. 2300-54.

Anic GM, Lee JH, Villa LL, Lazcano-Ponce E, Gage C, Jose CSR, et al. Risk factors for incident condyloma in a multinational cohort of men: the HIM study. J Infect Dis. 2012;205(5):789-93.

Chang GJ, Welton ML. Human papillomavirus, condylomata acuminata, and anal neoplasia. Clin Colon Rectal Surg. 2004;17(4):221-30.

Hernandez-Suarez G, Pineros M, Vargas JC, Orjuela L, Hernandez F, Peroza C, et al. Human papillomavirus genotypes in genital warts in Latin America: a cross-sectional study in Bogotá, Colombia. Int J STD AIDS. 2013;24(7):567-72.

Azevedo J, Pista A, Lisboa C, Santo I, Azevedo L, Cunha MJ. Epidemiology of human papillomavirus on anogenital warts in Portugal - The HERCULES study. J Eur Acad Dermatol Venereol. 2017;31(8):1342-8.

Kargi E, Gungor E, Tuncel A, Alli N, Erdogan B. Bowenoid papulosis. Ann Plast Surg. 2003;50(1):109-10.

Campione E, Centonze C, Diluvio L, Orlandi A, Cipriani C, Di Stefani A, et al. Bowenoid papulosis and invasive Bowen 's disease: a multidisciplinary approach. Acta Derm Venereol. 2013;93(2):228-9.

Zhang J, Zhang Y, Zhang Z. Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. PLoS One. 2018;13(9):e0204162.

Garland SM, Joura EA, Ault KA, Bosch FX, Brown DR, Castellsague X, et al. Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. Obstet Gynecol. 2018;132(2):261-70.

Lopez N, Gil-de-Miguel A, Pascual-Garcia R, Gil-Prieto R. Hospitalizations associated with malignant neoplasia and in situ carcinoma in the anus and penis in men and women during a 5-year period (2009-2013) in Spain: An epidemiological study. Hum Vaccin Immunother. 2017;13(10):2292-9.

Arrabal-Polo MA, Girón-Prieto MS, Orgaz-Molina J, Merino-Salas S, Lopez-Carmona F, Arrabal-Martin M, et al. Clinical Manifestations of the Human Papillomavirus. In: Broeck DV, editor. Human Papillomavirus and Related Diseases From Bench to Bedside A Diagnostic and Preventive Perspective: InTech; 2013.

Ritu N, Wilbur DC. The Bethesda System for Reporting Cervical Cytology. Third ed. Chicago , IL. USA: Springer; 2014. 342 p.

Solomon D, Davey D, Kurman R, Moriarty A, O’Connor D, Prey M, et al. The 2001 Bethesda System. Terminology for Reporting Results of Cervical Cytology. JAMA. 2002;287(16):2114-9.

Richart RM. Screening. The next century. Cancer. 1995;76(10 Suppl):1919-27.

Gilani SM, Tashjian R, Fathallah L. Cervical cytology with a diagnosis of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a follow-up study with corresponding histology and significance of predicting dysplasia by human papillomavirus (HPV) DNA testing. Arch Gynecol Obstet. 2014;289(3):645-8.

Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer. 2007;7(1):11-22.

Yalcin I, Sari ME, Sahin H, Gultekin M, Gungor T, Meydanli MM. Colposcopic biopsy findings among women with either HPV-16 only or HPV-18 only who have normal cervical cytology. Int J Gynaecol Obstet. 2018;143(3):300-5.

Andía D, Castro M, de la Fuente J, Hernández JJ, López JA, Martínez JC, et al. AEPCC- Guía: COLPOSCOPIA. ESTÁNDARES DE CALIDAD. In: AEPCC P, editor. España: Asociación Española de Patología Cervical y Colposcopia; 2018. p. 1-80.

Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain JM, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. J Low Genit Tract Dis. 2012;16(3):175-204.

Evans MF, Adamson CS, Papillo JL, St John TL, Leiman G, Cooper K. Distribution of human papillomavirus types in ThinPrep Papanicolaou tests classified according to the Bethesda 2001 terminology and correlations with patient age and biopsy outcomes. Cancer. 2006;106(5):1054-64.

Franceschi S, Clifford GM. Re: A study of the impact of adding HPV types to cervical cancer screening and triage tests. J Natl Cancer Inst. 2005;97(12):938-9; author reply 9-41.

Franceschi S, Herrero R, Clifford GM, Snijders PJ, Arslan A, Anh PT, et al. Variations in the age-specific curves of human papillomavirus prevalence in women worldwide. Int J Cancer. 2006;119(11):2677-84.

Joura EA, Ault KA, Bosch FX, Brown D, Cuzick J, Ferris D, et al. Attribution of 12 high- risk human papillomavirus genotypes to infection and cervical disease. Cancer Epidemiol Biomarkers Prev. 2014;23(10):1997-2008.

Soto-De Leon S, Camargo M, Sanchez R, Munoz M, Perez-Prados A, Purroy A, et al. Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors. PLoS One. 2011;6(2):e14705.

Capote LG. Epidemiology of cervical cancer in Latin America. Ecancer. 2015;9:577.

Watson-Jones D, Baisley K, Brown J, Kavishe B, Andreasen A, Changalucha J, et al. High prevalence and incidence of human papillomavirus in a cohort of healthy young African female subjects. Sex Transm Infect. 2013;89(5):358-65.

Lupato V, Holzinger D, Hofler D, Menegaldo A, Giorgi Rossi P, Del Mistro A, et al. Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy. PLoS One. 2017;12(1):e0170091.

Collins SI, Mazloomzadeh S, Winter H, Rollason TP, Blomfield P, Young LS, et al. Proximity of first intercourse to menarche and the risk of human papillomavirus infection: a longitudinal study. Int J Cancer. 2005;114(3):498-500.

Dmoch-Gajzlerska E, Kozakiewicz B, Chadzynska M. Women's knowledge regarding the effects of cigarette smoking and human papillomavirus infection on the development of cervical cancer. Clin Oncol (R Coll Radiol). 2014;26(6):358.

Louie KS, Castellsague X, de Sanjose S, Herrero R, Meijer CJ, Shah K, et al. Smoking and passive smoking in cervical cancer risk: pooled analysis of couples from the IARC multicentric case-control studies. Cancer Epidemiol Biomarkers Prev. 2011;20(7):1379-90.

Alam S, Conway MJ, Chen HS, Meyers C. The cigarette smoke carcinogen benzo[a]pyrene enhances human papillomavirus synthesis. J Virol. 2008;82(2):1053-8.

Wei L, Griego AM, Chu M, Ozbun MA. Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes. Carcinogenesis. 2014;35(10):2373-81.

Tarney CM, Beltran TA, Klaric J, Han JJ. Tobacco Use and Prevalence of Human Papillomavirus in Self-Collected Cervicovaginal Swabs Between 2009 and 2014. Obstet Gynecol. 2018;132(1):45-51.

Belinson S, Smith JS, Myers E, Olshan A, Belinson J, Pretorius R, et al. Descriptive evidence that risk profiles for cervical intraepithelial neoplasia 1, 2, and 3 are unique. Cancer Epidemiol Biomarkers Prev. 2008;17(9):2350-5.

Jensen KE, Schmiedel S, Norrild B, Frederiksen K, Iftner T, Kjaer SK. Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up. Br J Cancer. 2013;108(1):234-9.

Hellberg D. Sex steroids and cervical cancer. Anticancer Res. 2012;32(8):3045-54.

Castellsague X, Ghaffari A, Daniel RW, Bosch FX, Munoz N, Shah KV. Prevalence of penile human papillomavirus DNA in husbands of women with and without cervical neoplasia: a study in Spain and Colombia. J Infect Dis. 1997;176(2):353-61.

Morris BJ, Hankins CA, Banerjee J, Lumbers ER, Mindel A, Klausner JD, et al. Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions? Frontiers in public health. 2019;7:4.

La Vecchia C, Boccia S. Oral contraceptives, human papillomavirus and cervical cancer. Eur J Cancer Prev. 2014;23(2):110-2.

Green J, Berrington de Gonzalez A, Smith JS, Franceschi S, Appleby P, Plummer M, et al. Human papillomavirus infection and use of oral contraceptives. Br J Cancer. 2003;88(11):1713-20.

Chagas BS, Gurgel A, Paiva Junior SSL, Lima RCP, Cordeiro MN, Moura RR, et al. Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions. Genet Mol Res. 2017;16(3).

Koshiyama M. The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers. Healthcare (Basel, Switzerland). 2019;7(3).

Human Papillomavirus and Related Diseases Report. Cuba: ICO Information Centre on HPV and Cancer, 2014.

Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, et al. A review of human carcinogens--Part B: biological agents. Lancet Oncol. 2009;10(4):321-2.

Bernard E, Pons-Salort M, Favre M, Heard I, Delarocque-Astagneau E, Guillemot D, et al. Comparing human papillomavirus prevalences in women with normal cytology or invasive cervical cancer to rank genotypes according to their oncogenic potential: a meta-analysis of observational studies. BMC Infect Dis. 2013;13(1):373.

Carozzi F, De Marco L, Gillio-Tos A, Del Mistro A, Girlando S, Baboci L, et al. Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence. J Clin Virol. 2014;60(3):257-63.

Memon A, Bannister P. Epidemiology of Cervical Cancer. In: Farghaly SA, editor. Uterine Cervical Cancer. 1. 1 ed: Springer International Publishing; 2019. p. 1-16.

Negrin LGC. Epidemiology of cervical cancer in Latin America. Ecancer. 2015;9:1-14.

Arbyn M, Castellsague X, de Sanjose S, Bruni L, Saraiya M, Bray F, et al. Worldwide burden of cervical cancer in 2008. Ann Oncol. 2011;22(12):2675-86.

Castro FA, Dominguez A, Puschel K, Van De Wyngard V, Snijders PJ, Franceschi S, et al. Serological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chile. BMC Infect Dis. 2014;14:361.

Abreu AL, Souza RP, Gimenes F, Consolaro ME. A review of methods for detecting human Papillomavirus infection. Virol J. 2012;9:262.

Villa LL, Denny L. Methods for detection of HPV infection and its clinical utility. Int J Gyn Obst 2006, 94:71– 80. Int J Gyn Obst. 2006;94:71-80.

Bartlett B, Stirling CT. A Short History of the Polymerase Chain Reaction. Methods Mol Biol. 2003;226:3-6.

de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ. The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol. 1995;76 ( Pt 4):1057- 62.

Jacobs MV, de Roda Husman AM, van den Brule AJ, Snijders PJ, Meijer CJ, Walboomers JM. Group-specific differentiation between high- and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes. J Clin Microbiol. 1995;33(4):901-5.

Camargo M, Soto-De Leon S, Sánchez R, Munoz M, Vega E, Beltran M, et al. Detection by PCR of human papillomavirus in Colombia: Comparison of GP5+/6+ and MY09/11 primer sets. J Virol Methods. 2011;178(1-2):68-74.

Prasongdee P, Tippayawat P, Limpaiboon T, Leelayuwat C, Wongwattanakul M, Jearanaikoon P. The development of simultaneous measurement of viral load and physical status for human papillomavirus 16 and 18 co-infection using multiplex quantitative polymerase chain reaction. Oncol Lett. 2018;16(6):6977-87.

Chan PK, Picconi MA, Cheung TH, Giovannelli L, Park JS. Laboratory and clinical aspects of human papillomavirus testing. Crit Rev Clin Lab Sci. 2012;49(4):117-36.

Castle PE, Wheeler CM, Solomon D, Schiffman M, Peyton CL. Interlaboratory reliability of Hybrid Capture 2. Am J Clin Pathol. 2004;122(2):238-45.

Aggarwal P. Cervical cancer: Can it be prevented? World journal of clinical oncology. 2014;5(4):775-80.

Yadav R, Zhai L, Tumban E. Virus-like Particle-Based L2 Vaccines against HPVs: Where Are We Today? Viruses. 2020;12(1).

Bharadwaj M, Hussain S, Nasare V, Das BC. HPV & HPV vaccination: issues in developing countries. Indian J Med Res. 2009;130(3):327-33.

Serrano B, Alemany L, Tous S, Bruni L, Clifford GM, Weiss T, et al. Potential impact of a nine-valent vaccine in human papillomavirus related cervical disease. Infect Agent Cancer. 2012;7(1):38.

Virus del papiloma humano. 2020. In: Manual de vacunas en línea de la AEP [Internet]. Madrid: AEP. Available from: http://vacunasaep.org/documentos/manual/cap-42.

Haghshenas MR, Mousavi T, Kheradmand M, Afshari M, Moosazadeh M. Efficacy of Human Papillomavirus L1 Protein Vaccines (Cervarix and Gardasil) in Reducing the Risk of Cervical Intraepithelial Neoplasia: A Meta-analysis. International journal of preventive medicine. 2017;8:44.

Gilca V, Sauvageau C, Panicker G, De Serres G, Ouakki M, Unger ER. Antibody persistence after a single dose of quadrivalent HPV vaccine and the effect of a dose of nonavalent vaccine given 3-8 years later - an exploratory study. Hum Vaccin Immunother. 2019;15(2):503-7.

Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, et al. A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women. N Engl J Med. 2015;372(8):711-23.

Shah PD, Calo WA, Gilkey MB, Boynton MH, Alton Dailey S, Todd KG, et al. Questions and Concerns About HPV Vaccine: A Communication Experiment. Pediatrics. 2019;143(2).

Orellana-Amoroso TM. Importancia del turismo comunitario para el desarrollo de las comunidades cañaris [Tesis para la obtención del título de ingeniera en turismo]. Ecuador: Universidad de Cuenca; 2011.

Nugus P, Desalliers J, Morales J, Graves L, Evans A, Macaulay AC. Localizing Global Medicine: Challenges and Opportunities in Cervical Screening in an Indigenous Community in Ecuador. Qual Health Res. 2018;28(5):800-12.

Asotic A, Taric S, Asotic J. Correlation of cervical smear and pathohistological findings. Med Arch. 2014;68(2):106-9.

Cerqueira EM, Santoro CL, Donozo NF, Freitas BA, Pereira CA, Bevilacqua RG, et al. Genetic damage in exfoliated cells of the uterine cervix. Association and interaction between cigarette smoking and progression to malignant transformation? Acta Cytol. 1998;42(3):639-49.

Noller KL. Intraepithelial neoplasia of the lower genital tract (cervix, vulva): etiology, screening, diagnostic techniques, management In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, editors. Comprehensive Gynecology. 5th ed. Philadelphia, Pe: Mosby Elsevier; 2007.

Denny L. Cytological screening for cervical cancer prevention. Best Pract Res Clin Obstet Gynaecol. 2012;26(2):189'96.

Roe CJ, Hanley KZ. Updates in Cervical Cytology: The 90-Year-Long Journey from Battle Creek to Today. Surgical pathology clinics. 2018;11(3):589-99.

Papanicolaou GN. A NEW PROCEDURE FOR STAINING VAGINAL SMEARS. Science. 1942;95(2469):438-9.

Bonde J, Rebolj M, Ejegod DM, Preisler S, Lynge E, Rygaard C. HPV prevalence and genotype distribution in a population-based split-sample study of well-screened women using CLART HPV2 human papillomavirus genotype microarray system. BMC Infect Dis. 2014;14:413.

Del Pino M, Alonso I, Rodriguez-Trujillo A, Bernal S, Geraets D, Guimera N, et al. Comparison of the analytical and clinical performance of five tests for the detection of human papillomavirus genital infection. J Virol Methods. 2017;248:238-43.

Wang W, Zhang XH, Li M, Hao CH, Zhao ZM, Liang HP. Association between viral loads of different oncogenic human papillomavirus types and the degree of cervical lesions in the progression of cervical Cancer. Clin Chim Acta. 2018;483:249-55.

Helsinki. Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2018;310(20):2191-94.

Van Delden J, Van der Graaf R. Revised CIOMS International Ethical Guidelines for Health-Related Research Involving Humans. JAMA. 2016;317(2):135-6.

Jaruseviciene L, Orozco M, Ibarra M, Ossio FC, Vega B, Auquilla N, et al. Primary healthcare providers' views on improving sexual and reproductive healthcare for adolescents in Bolivia, Ecuador, and Nicaragua. Glob Health Action. 2013;6:20444.

Mendoza L, Mongelos P, Paez M, Castro A, Rodriguez-Riveros I, Gimenez G, et al. Human papillomavirus and other genital infections in indigenous women from Paraguay: a cross- sectional analytical study. BMC Infect Dis. 2013;13:531.

Urrutia MT, Concha X, Riquelme G, Padilla O. [Knowledge and preventive behaviors related to cervical cancer and human papilloma virus in a group of Chilean adolescents]. Rev Chilena Infectol. 2012;29(6):600-6.

Demers AA, Shearer B, Severini A, Lotocki R, Kliewer EV, Stopera S, et al. Distribution of human papillomavirus types, cervical cancer screening history, and risk factors for infection in Manitoba. Chronic Dis Inj Can. 2012;32(4):177-85.

Lee CH, Peng CY, Li RN, Chen YC, Tsai HT, Hung YH, et al. Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes. Int J Cancer. 2015;136(2):340-9.

Moore SP, Forman D, Pineros M, Fernandez SM, de Oliveira Santos M, Bray F. Cancer in indigenous people in Latin America and the Caribbean: a review. Cancer Med. 2014;3(1):70- 80.

WHO pushes first cervical cancer vaccine. Public Health Rep. 1999;114(3):211.

Stoler MH, Wright TC, Jr., Sharma A, Zhang G, Apple R, Wright TL, et al. The interplay of age stratification and HPV testing on the predictive value of ASC-US cytology. Results from the ATHENA HPV study. Am J Clin Pathol. 2012;137(2):295-303.

Wright TC, Jr., Behrens CM, Ranger-Moore J, Rehm S, Sharma A, Stoler MH, et al. Triaging HPV-positive women with p16/Ki-67 dual-stained cytology: Results from a sub-study nested into the ATHENA trial. Gynecol Oncol. 2017;144(1):51-6.

Ge Y, Christensen P, Luna E, Armylagos D, Xu J, Schwartz MR, et al. Aptima Human Papillomavirus E6/E7 mRNA Test Results Strongly Associated With Risk for High-Grade Cervical Lesions in Follow-Up Biopsies. J Low Genit Tract Dis. 2018;22(3):195-200.

Wright TC, Jr., Stoler MH, Behrens CM, Sharma A, Sharma K, Apple R. Interlaboratory variation in the performance of liquid-based cytology: Insights from the ATHENA trial. Int J Cancer. 2014;134(8):1835-43.

Bulten J, de Wilde PC, Boonstra H, Gemmink JH, Hanselaar AG. Proliferation in "atypical" atrophic pap smears. Gynecol Oncol. 2000;79(2):225-9.

Bulten J, de Wilde PC, Schijf C, van der Laak JA, Wienk S, Poddighe PJ, et al. Decreased expression of Ki-67 in atrophic cervical epithelium of post-menopausal women. J Pathol. 2000;190(5):545-53.

Cendales R, Wiesner C, Murillo RH, Piñeros M, Tovar S, Mejia JC. [Quality of vaginal smear for cervical cancer screening: a concordance study]. Biomédica. 2010;30(1):107-15.

Killeen JL, Dye T, Grace C, Hiraoka M. Improved Abnormal Pap Smear Triage Using Cervical Cancer Biomarkers. J Low Genit Tract Dis. 2013.

Programa Nacional de Salud Reproductiva: Componente cérvico-uterino. Manual para tamizaje del cáncer cérvico-uterino. In: Social MdSPyA, editor. Ecuador: Ministerio de Salud Pública; 2006.

Guía Clínica Cáncer cérvico-uterino. In: MINSAL. C, editor. Santiago de Chile: Guías Clínicas NINSAL; 2010.

Kitchener HC, Castle PE, Cox JT. Chapter 7: Achievements and limitations of cervical cytology screening. Vaccine. 2006;24 Suppl 3:S3/63-70.

González-Andrade F, Sánchez D. HPV genotyping in anogenital abnormal samples of Ecuadorian women. Cáncer Biomark. 2009;5(4):225-32.

Cabezas E, Camacho T, Santana A, Borrajero I, Aguilar F, Romero T, et al. Programa Diagnóstico Precoz del Cáncer de Cuello del Útero en Cuba. Cabezas Cruz E, editor. La Habana, Cuba: Ministerio de Salud Pública de Cuba; 1999.

Anuario Estadístico de Salud 2018. Especial ed. La Habana: Oficina Nacional de Estadísticas e Información de la Dirección Nacional de Registros Médicos del Ministerio de Salud Pública de Cuba; 2019. p. 1-206.

Tracht J, Wrenn A, Eltoum IE. Primary HPV testing verification: A retrospective ad-hoc analysis of screening algorithms on women doubly tested for cytology and HPV. Diagn Cytopathol. 2017;45(7):580-6.

Flores YN, Bishai DM, Lorincz A, Shah KV, Lazcano-Ponce E, Hernandez M, et al. HPV testing for cervical cancer screening appears more cost-effective than Papanicolau cytology in Mexico. Cancer Causes Control. 2011;22(2):261-72.

Badano I, Pedrozo RW, Ruiz Diaz LS, Galuppo JA, Picconi MA, Campos RH, et al. Detección del virus papiloma humano (HPV) y citología de Papanicolaou en mujeres de bajos recursos de la ciudad de Posadas, Misiones, Argentina. Rev Argent Microbiol. 2011;43(4):263-7.

Brown CR, Leon ML, Munoz K, Fagioni A, Amador LG, Frain B, et al. Human papillomavirus infection and its association with cervical dysplasia in Ecuadorian women attending a private cancer screening clinic. Braz J Med Biol Res. 2009;42(7):629-36.

Cabrera JA, Cárdena OJ, Campoverde MA, Ortiz JI. Prevalencia de genotipos del papiloma virus humano en mujeres de la provincia del Azuay, Ecuador. MASKANA. 2015;6(1):79-93.

Bruni L, Diaz M, Castellsague X, Ferrer E, Bosch FX, de Sanjose S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis. 2010;202(12):1789-99.

Aguilar-Lemarroy A, Vallejo-Ruiz V, Cortes-Gutierrez EI, Salgado-Bernabe ME, Ramos- Gonzalez NP, Ortega-Cervantes L, et al. Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: type-specific prevalence and HPV coinfections. J Med Virol. 2015;87(5):871-84.

Bruno A, Serravalle K, Travassos AG, Lima BG. [Genotype distribution of human papillomavirus in women from the state of Bahia, Brazil]. Rev Bras Ginecol Obstet. 2014;36(9):416-22.

Wang XC, Sun LQ, Ma L, Li HX, Wang XL, Wang X, et al. Prevalence and genotype distribution of human papillomavirus among women from Henan, China. Asian Pac J Cancer Prev. 2014;15(17):7333-6.

Sun B, He J, Chen X, He M, He Z, Wang Y, et al. Prevalence and genotype distribution of human papillomavirus infection in Harbin, Northeast China. Arch Virol. 2014;159(5):1027-32.

Ortega-Cervantes L, Aguilar-Lemarroy A, Rojas-Garcia AE, Barron-Vivanco BS, Vallejo-Ruiz V, Leon DC, et al. Human papilloma virus genotypes in women from Nayarit, Mexico, with squamous intraepithelial lesions and cervical cancer. International journal of health sciences. 2016;10(3):327-38.

Guilarte-García E, Soto-Brito Y, Kourí-Cardellá V, Limia-León CM, Sánchez-Alvarez ML, Rodríguez-Díaz AE, et al. Circulation of Human Papillomavirus and Chlamydia trachomatis in Cuban Women. MEDICC Review. 2020;22(1):17-27.

Tornesello ML, Buonaguro L, Izzo S, López G, Vega X, Maldonado Reyes CF, et al. A pilot study on the distribution of human papillomavirus genotypes and HPV-16 variants in cervical neoplastic lesions from Ecuadorian women. J Med Virol. 2008;80(11):1959-65.

Alemany L, Saunier M, Tinoco L, Quiros B, Alvarado-Cabrero I, Alejo M, et al. Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples. Eur J Cancer. 2014;50(16):2846-54.

Vaccarella S, Soderlund-Strand A, Franceschi S, Plummer M, Dillner J. Patterns of human papillomavirus types in multiple infections: an analysis in women and men of the high throughput human papillomavirus monitoring study. PLoS One. 2013;8(8):716-17.

Romero-Morelos P, Uribe-Jimenez A, Bandala C, Poot-Velez A, Ornelas-Corral N, Rodriguez-Esquivel M. Genotyping of human papilloma virus in a group of Mexican women treated in a highly specialist hospital: Multiple infections and their potential transcendence in the current vaccination programme. Med Clin (Barc). 2017;149((7)):287-92.

Wentzensen N, Schiffman M, Dunn T, Zuna RE, Gold MA, Allen RA, et al. Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants. Int J Cancer. 2009;125(9):2151-8.

Wentzensen N, Nason M, Schiffman M, Dodd L, Hunt WC, Wheeler CM. No evidence for synergy between human papillomavirus genotypes for the risk of high-grade squamous intraepithelial lesions in a large population-based study. J Infect Dis. 2014;209(6):855-64.

De Brot L, Pellegrini B, Moretti ST, Carraro DM, Soares FA, Rocha RM, et al. Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix. Cancer Cytopathol. 2017;125(2):138-43.

Salazar KL, Zhou HS, Xu j, Peterson LE, Schwartz MR, Mody DR, et al. Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions. Acta Cytol. 2015;59:391–8.

Sobota RS, Ramogola-Masire D, Williams SM. Co-infection with HPV types from the same species provides natural cross-protection from progression to cervical cancer. Infect Agent Cancer. 2018 9(2):26-30.

Giambi C, Donati S, Carozzi F, Salmaso S, Declich S, Atti ML, et al. A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18-26 years. BMC Infect Dis. 2013;13:74.

de Oliveira GR, Vieira VC, Avila EC, Finger-Jardim F, Caldeira TD, Gatti FA, et al. Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions. Mem Inst Oswaldo Cruz. 2017;112(7):492-8.

Bienkowska-Haba M, Luszczek W, Myers JE, Keiffer TR, DiGiuseppe S, Polk P, et al. A new cell culture model to genetically dissect the complete human papillomavirus life cycle. PLoS Pathog. 2018;14(3):e1006846.

Schmitt M, Depuydt C, Benoy I, Bogers J, Antoine J, Arbyn M, et al. Multiple human papillomavirus infections with high viral loads are associated with cervical lesions but do not differentiate grades of cervical abnormalities. J Clin Microbiol. 2013;51(5):1458-64.

Oyervides-Muñoz MA, Pérez-Maya AA, Sánchez-Domínguez CN, Berlanga-Garza A, Antonio-Macedo M, Valdéz-Chapa LD, et al. Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women. Viruses. 2020;12(380):1-12.

Wang W, Zhang X, Li M, Hao C, Liang H. Association between Vaginal Infections and the Types and Viral Loads of Human Papillomavirus: A Clinical Study Based on 4,449 Cases of Gynecologic Outpatients. Can J Infect Dis Med Microbiol. 2020;2020.

Scarpini CG, Groves IJ, Pett MR, Ward D, Coleman N. Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes. J Pathol. 2014;233(3):281-93.

Kim J, Kim BK, Jeon D, Lee CH, Roh JW, Kim JY, et al. Type-Specific Viral Load and Physical State of HPV Type 16, 18, and 58 as Diagnostic Biomarkers for High-Grade Squamous Intraepithelial Lesions or Cervical Cancer. Cancer Res Treat. 2020;52(2):396-405.

Wu Z, Qin Y, Yu L, Lin C, Wang H, Cui J, et al. Association between human papillomavirus (HPV) 16, HPV18, and other HR-HPV viral load and the histological classification of cervical lesions: Results from a large-scale cross-sectional study. J Med Virol. 2017;89(3):535-41.

Del Río-Ospina L, Soto de Leon SC, Camargo M, Sánchez R, Moreno-Perez DA, Perez- Prados A, et al. Multiple high-risk HPV genotypes are grouped by type and are associated with viral load and risk factors. Epidemiol Infect. 2017;145(7):1479-90.

Barrios L, Benedetti I, Alvis L, Arroyo B. Conocimientos, actitudes y prácticas sobre la citología cérvico-uterina en mujeres de Sincelejo y Cartagena. Colombia. Rev Cienc Biomed. 2011;2(22):249-55.

Smith EM, Ritchie JM, Levy BT, Zhang W, Wang D, Haugen TH, et al. Prevalence and persistence of human papillomavirus in postmenopausal age women. Cancer Detect Prev. 2003;27(6):472-80.

Banister CE, Messersmith AR, Chakraborty H, Wang Y, Spiryda LB, Glover SH, et al. HPV prevalence at enrollment and baseline results from the Carolina Women's Care Study, a longitudinal study of HPV persistence in women of college age. Int J Womens Health. 2013;5:379-88.

Wiesner C, Acosta J, Diaz Del Castillo A, Tovar S. Social representations of human papillomavirus in Bogotá, Colombia. Med Anthropol. 2012;31(1):77-92.

de Sanjosé S, Wheeler CM, Quint WG, Hunt WC, Joste NE, Alemany L, et al. Age- specific occurrence of HPV16- and HPV18-related cervical cancer. Cancer Epidemiol Biomarkers Prev. 2013;22(7):1313-8.

Monsonego J, Zerat L, Syrjanen K, Zerat JC, Smith JS, Halfon P. [Prevalence of genotype-specific HPV infection among women in France: implications for screening and vaccination]. Gynecol Obstet Fertil. 2013;41(5):305-13.

Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, et al. Prevalence of HPV infection among females in the United States. JAMA. 2007;297(8):813-9.

Howell-Jones R, de Silva N, Akpan M, Oakeshott P, Carder C, Coupland L, et al. Prevalence of human papillomavirus (HPV) infections in sexually active adolescents and young women in England, prior to widespread HPV immunization. Vaccine. 2012;30(26):3867-75.

Rysavy MB, Kresowik JD, Liu D, Mains L, Lessard M, Ryan GL. Human papillomavirus vaccination and sexual behavior in young women. J Pediatr Adolesc Gynecol. 2014;27(2):67-71.

Malagón T, Drolet M, Boily MC, Franco EL, Jit M, Brisson J, et al. Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(10):781-9.

Zahnd WE, Rodriguez C, Jenkins WD. Rural-Urban Differences in Human Papillomavirus-associated Cancer Trends and Rates. J Rural Health. 2019;35(2):208-15.

Raychaudhuri S, Mandal S. Socio-demographic and behavioural risk factors for cervical cancer and knowledge, attitude and practice in rural and urban areas of North Bengal, India. Asian Pac J Cancer Prev. 2012;13(4):1093-6.

Vinodhini K, Shanmughapriya S, Das BC, Natarajaseenivasan K. Prevalence and risk factors of HPV infection among women from various provinces of the world. Arch Gynecol Obstet. 2012;285(3):771-7.

Marks M, Gravitt PE, Gupta SB, Liaw KL, Kim E, Tadesse A, et al. The association of hormonal contraceptive use and HPV prevalence. Int J Cancer. 2011;128(12):2962-70.

Ramírez-López IG, Ramírez de Arellano A, Jave-Suárez LF, Hernández-Silva CD, García-Chagollan M, Hernández-Bello J, et al. Interaction between 17β-estradiol, prolaction and human papillomavirus induce E6/E7 transcript and modulate the expression and localization of hormonal receptors. Cancer Cell Int. 2019;19:227.

Cruz-Saco MA. Indigenous communities and social inclusion in Latin America. In: Societies UNEG FaI, editor. New York, USA Connecticut College; 2018

Publicado

enero 26 2024

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Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Detalles sobre esta monografía

ISBN-13 (15)

978-9942-7159-7-5

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05-02-2024

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210mm x 297mm